〔Abstract〕 Objective To explore the effect of Child Life nursing model in perioperative nursing of children with congenital heart disease. Methods Eighty children with congenital heart disease admitted to Fuwai Central China Cardiovascular Hospital from April to July 2021 were selected and grouped according to the order of admission time. The children admitted from April to May 2021 were divided into a control group and those admitted from June to July 2021 were divided into an observation group, with 40 cases in each group. Children in the control group were given perioperative routine nursing, and children in the observation group were combined with Child Life nursing mode on the basis of the control group. The fear psychology and nursing treatment compliance of the two groups were compared. Results After nursing, the scores of child medical fear scale (CMFS) in the two groups were lower than that before nursing, and the observation group was lower than that in the control group, the difference was statistically significant (P < 0.05). The scores of the nursing treatment compliance scale in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion The application of Child Life nursing mode in the perioperative period of children with congenital heart disease can effectively reduce their fear in medical activities, enhance their compliance with nursing treatment, maintain their mental health, and improve medical quality.