〔Abstract〕 Objective To analyze the effect of Yijing Huchao decoction combined with gonadotropin-releasing hormone agonistst (GnRH-a) in the treatment of ovarian dysfunction infertility and its impact on ovarian function and pregnancy outcomes. Methods A total of 102 patients with ovarian insufficiency infertility admitted to Anshun Traditional Chinese Medicine Hospital from January 2020 to November 2022 as the research subjects. According to the treatment method, they were divided into a control group (51 cases, treated with GnRH-a) and an observation group (51 cases, treated with Yijing Huchao decoction combined with GnRH-a). The clinical efficacy, traditional Chinese medicine symptom score, ovarian function, endometrial thickness, number of antral follicles, pregnancy outcome, and adverse reactions of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group; After treatment, the scores of main symptoms, secondary symptoms, and accompanying symptoms in the observation group were lower than those in the control group; The serum levels of luteinizing hormone, follicle stimulating hormone, and testosterone in the observation group were lower than those in the control group, while the level of estradiol was higher than that in the control group; The thickness of the endometrium and the number of antral follicles in the observation group were higher than those in the control group; The pregnancy rate of the observation group was higher than that of the control group; The incidence of adverse reactions in the observation group was lower than that in the control group. The above differences are statistically significant (P < 0.05). Conclusion The combination of Yijing Huchao decoction and GnRH-a can improve ovarian function and pregnancy outcomes, and reduce the incidence of adverse reactions in the treatment of ovarian dysfunction infertility.