〔Abstract〕 Objective To investigate the clinical efficacy of Chaihu Plus Longgu Muli decoction in the treatment of coronary heart disease (CHD) complicated with depression. Methods A total of 84 patients diagnosed with CHD complicated with depression from August 2021 to June 2023 at Youxi Hospital of Traditional Chinese Medicine were selected and divided into a control group and an observation group according to the random number table method, with 42 cases in each group. Patients in the control group were given conventional Western medical treatment, while patients in the observation group were treated with Chaihu Plus Longgu Muli decoction in addition to the treatment of the control group, with a course of 12 weeks. The efficacy, traditional Chinese medicine syndromes, cardiac function, and inflammatory indicators before and after treatment were compared between the two groups. Results The total effective rate in the observation group was 95.24%, which was higher than the 78.57% in the control group, and the difference was statistically significant (P < 0.05); after treatment, the scores of traditional Chinese medicine syndromes (chest pain, chest tightness, and irritability) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05); after treatment, the cardiac output (CO) and left ventricular ejection fraction (LVEF) in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05); after treatment, the levels of serum interleukin-6 (IL-6) and C-reactionprotein (CRP) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Chaihu Plus Longgu Muli decoction has a significant adjuvant effect in the treatment of CHD patients complicated with depression, and it can accelerate the relief of symptoms, promote the clearance of inflammation, and restore cardiac function in these patients.