〔Abstract〕 Objective To analyze the factors affecting the interruption of enteral nutrition support after tetralogy of Fallot (TOF) in infants and young children based on structural equation model, and to propose intervention strategies. Methods A total of 86 children with TOF surgery admitted to Fuwai Central China Cardiovascular Hospital from February 2021 to February 2023 were selected for retrospective analysis. Postoperative enteral nutrition support was given, and the patients were divided into interrupted group (50 cases) and noninterrupted group (36 cases) according to whether the enteral nutrition support was interrupted. The baseline data of the two groups of children were collected, and the influencing factors of postoperative enteral nutrition support interruption in infants and young children with TOF were identified by multi-factor logistic regression model, and the structural equation model was used for analysis. Results Multivariate logistic regression results showed that feeding intolerance, bedside operation frequency and tube feeding failure were independent risk factors for postoperative enteral nutrition support interruption in infants and young children with TOF (P < 0.05). Structural equation model analysis showed that the path coefficients (direct effects) of feeding intolerance, bedside operation times and tube feeding failure on enteral nutritional support interruption were 0.77, 0.64 and 0.53 (all P < 0.05). Conclusion The interruption of enteral nutrition support in infants and young children with TOF is related to feeding intolerance, bedside operation frequency and tube feeding failure. Clinical attention should be paid to adjusting nutrition support program according to the situation to reduce the interruption frequency or shorten the interruption time.