〔Abstract〕 Objective To investigate the effect of early rehabilitation training frequency after percutaneous coronary intervention (PCI) on clinical indexes of patients with acute myocardial infarction (AMI). Methods A total of 196 AMI patients who received PCI treatment in the 7th People's Hospital of Zhengzhou from January 2023 to January 2024 were selected for inclusion in this study. According to the frequency of early rehabilitation training after PCI, the enrolled patients were divided into a conventional group and a high-frequency group, with 98 cases in each group. After 1 month of training, the cardiac function indexes, activity endurance indexes, stress response indexes and lung function indexes were compared between the two groups. Results After training, the left ventricular ejection fractions (LVEF) in the high-frequency group was higher than that in the conventional group, and the left ventricular end diastolic volume (LVEDV) and left ventricular end systolic volume (LVESV) were lower than those in the conventional group, with statistical significance (P < 0.05). After training, the maximum exercise power, maximum exercise time and 6-minute walk test (6MWT) in the high-frequency group were higher than those in the conventional group, and the differences were statistically significant (P < 0.05). After training, the serum levels of myeloperoxidase (MPO), hypersensitive C-reactive protein (hs-CRP), soluble intercellular cell adhesion molecule-1 (SICAM-1) and nuclear factor kappa-B (NF-κB) in the high-frequency group were lower than those in the conventional group, and the differences were statistically significant (P < 0.05). After training, the forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and peak expiratory flow (PEF) in the high-frequency group were higher than those in the conventional group, and the differences were statistically significant (P < 0.05). Conclusion Early and high frequency rehabilitation training after PCI can better improve the cardiopulmonary function and enhance the activity endurance of AMI patients after PCI.