〔Abstract〕 Objective To investigate the pain management knowledge level and pain management attitude of the fourth or fifth grade medical students in the Fifth Clinical Medical College of Henan University of Chinese Medicine. Methods A total of 160 fourth or fifth grade medical students from the Fifth Clinical Medical College of Henan University of Chinese Medicine, who rotated from September 2021 to February 2022 were selected as the survey subjects. The pain management knowledge and attitude survey questionnaire (KASRP) (2014 version) was used for the survey. Results The average correct answer rate of senior medical students was (43.58 ± 8.23)% and the average correct answer number was (17.00 ± 3.21). Through multiple linear regression analysis, the results showed that "whether you know the pathological characteristics of pain" and "whether you know the pain assessment tools" were the influential factors of the correct response rate of the questionnaire (P < 0.01). Conclusion The fourth or fifth grade medical students at the Fifth Clinical Medical College of Henan University of Chinese Medicine have insufficient knowledge of pain management. The education of pain specialized courses and the clinical practice of pain in medical institutions are factors that affect the pain cognition level of medical students.