〔Abstract〕 Objective To analyze the influencing factors of patients' satisfaction with screening and intervention programs for high-risk population of stroke in northern Guangdong, and provide theoretical guidance for screening and intervention for high-risk population of stroke in northern Guangdong. Methods A questionnaire survey was conducted among 305 patients who received screening and intervention for high-risk population of stroke in northern Guangdong. The time range was from January 2022 to December 2023. The main contents included the basic situation of patients and satisfaction evaluation. The distribution of patients' satisfaction was analyzed, and then the influencing factors of patients' satisfaction were analyzed by multivariate logistic regression model. Results Among the 305 patients, 47 cases (18.22%) were satisfied and 258 cases (81.78%) were dissatisfied. There were statistically significant differences between the two groups in hazard cognition, attitude of medical staff, medical treatment process, hospitalization health education methods, hospitalization health education contents, medical treatment environment, discharge education methods, discharge education contents, medical treatment expenses, follow-up methods, follow-up times and reexamination satisfaction (P < 0.05). Multivariate logistic regression analysis showed that low awareness of harm (OR = 4.677, P = 0.004) and dissatisfaction with medical expenses (OR = 3.673, P = 0.009) were independent risk factors for patient satisfaction. Conclusion Full attention should be paid to the influencing factors of patients' satisfaction with the current screening and intervention programs for high-risk groups of stroke, take the risk cognition and medical expenses as the development orientation, improve the service system of screening and intervention programs for high-risk groups of stroke, and meet the patient's diagnosis and treatment service.