〔Abstract〕 Objective To analyze the clinical application effect of the traditional Chinese medicine Yiqi Huoxue method combined with auricular acupoint bean embedding in patients with chemotherapy-induced peripheral neuropathy. Methods A total of 70 patients treated with vinca alkaloids, platinum, and taxanes at Taihe County Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were selected and divided into a control group and an observation group according to the random number table method, with 35 cases in each group. Patients in the control group were treated with western medicine alone, while patients in the observation group were additionally treated with traditional Chinese medicine based on syndrome differentiation, using the Yiqi Huoxue method combined with auricular acupoint bean embedding. Both groups were treated for 2 weeks. The incidence of peripheral neuropathy, duration and severity of symptoms, improvement of complications, and clinical efficacy were compared between the two groups. Results The incidence of peripheral neuropathy in the observation group was 52.43%, which was lower than 77.14% in the control group, and the difference was statistically significant (P < 0.05); the duration of peripheral neuropathy in the observation group was (17.62 ± 2.85) days, which was shorter than (27.98 ± 3.11) days in the control group, and the difference was statistically significant (P < 0.05); the severity of symptoms in the observation group was less than that in the control group, and the difference was statistically significant (Z = 19.707, P < 0.05); the scores of peripheral neuropathy complications (limb numbness, muscle strength reduction, achilles tendon reflex reduction) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05); the total effective rate of treatment in the observation group was 94.44%, which was higher than 62.96% in the control group, and the difference was statistically significant (P < 0.05). Conclusion The traditional Chinese medicine Yiqi Huoxue method combined with auricular acupoint bean embedding has a good therapeutic effect in patients with chemotherapy-induced peripheral neuropathy, significantly alleviating clinical symptoms, shortening the duration of symptoms, improving the degree of neuropathy, and promoting the improvement of complications of peripheral neuropathy.