〔Abstract〕 Objective Based on the results of Nutritional Risk Screening 2002 (NRS2002), the feasibility and effectiveness of different nutritional interventions in patients with advanced gastrointestinal tumors were investigated. Methods A total of 228 patients with advanced gastrointestinal tumors (inoperable) admitted to the Oncology Department of Nanyang Second People's Hospital from June 2022 to May 2023 were selected as the study objects. Nurses trained in the nutrition department applied NRS2002 daily for nutritional risk screening to determine the presence of nutritional risk. According to the treatment conditions of clinicians and patients' wishes, nutritional support methods were determined. Patients with gastrointestinal tumors with nutritional risks were divided into control group (single bottle parenteral nutrition treatment), observation group A ("all-in-one" parenteral nutrition treatment) and observation group B (enteral nutrition treatment). The changes of anxiety, depression, quality of life scores, adverse reactions and nutrition-related laboratory indicators before and after treatment were evaluated in patients with different nutritional support methods. Results After intervention, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS) and health-related quality of life (HRQOL) in Observation Group A and Observation Group B were lower than those in control group, with statistical significance (P < 0.05). The constipation and abdominal distension of observation group B was higher than that of control group, and the infection was lower than that of control group and observation group A, the difference was statistically significant (P < 0.05). After intervention, the levels of serum transferrin (TRF), albumin (ALB) and prealbumin (PA) in observation groups A and B were significantly higher than those in control group, with statistical significance (P < 0.05). Conclusion Nutritional support therapy has a positive significance in improving the nutritional indexes of patients, especially in patients who adopt enteral nutrition and "allin-one" parenteral nutrition therapy. However, no matter what kind of nutritional support can not greatly change the overall situation of disease development of patients.