〔Abstract〕 Objective To analyze the application value of portable sleep monitor devices (PMDs) and wristband oximeter in the diagnosis of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 128 patients who snored during nighttime sleep at Shishi City Hospital from August 2020 to March 2022 were selected as the study subjects. All patients underwent diagnosis using polysomnography (PSG), PMDs, and wristband oximeter. The diagnostic specificity, sensitivity, and accuracy of PMDs and wristband oximeter were compared based on the results of PSG examination. Results There were 111 positive patients and 17 negative patients detected by PSG monitoring; Using PSG monitoring results as the standard for analysis, there was no statistically significant difference in specificity, sensitivity, and accuracy between PMDs monitoring and wristband oximeter monitoring (P > 0.05). The indicators of sleep apnea hypopnea index (AHI), mean blood oxygen saturation, minimum blood oxygen saturation, and arterial blood oxygen saturation < 90% were compared among the three monitoring methods, and the differences were not statistically significant (P > 0.05). Conclusion Both PMDs and wristband oximeter have high diagnostic efficacy and are easy to carry and operate, which can be used for clinical and daily diagnosis of patients.