〔Abstract〕 Objective To explore the application of fluid manometry to monitor intestinal pressure in early enteral nutrition treatment of patients with severe neurological conditions. Methods A total of 90 patients with severe neurological conditions who had nasal jejunal nutrition tube placed in Henan Provincial People's Hospital from June 2022 to May 2023 were selected and divided into the conventional group and the fluid pressure measurement group according to random number table method, with 45 cases in each group. The conventional group assessed the intestinal function by measuring abdominal circumference and listening to intestinal sounds, while the fluid pressure measurement group monitored the intestinal pressure and intestinal function by fluid manometry. Compare the feeding compliance, feeding intolerance, nutritional indicators, and disease severity between the two groups of patients. Results The adjustment time of enteral nutrition, the standard feeding time of enteral nutrition and the length of intensive care unit (ICU) stay in the fluid pressure measurement group were shorter than those in the conventional group, and the rate of enteral nutrition compliance on the 5th day was higher than that in the conventional group, the differences were statistically significant (P < 0.05). The total incidence of feeding intolerance in the fluid pressure measurement group was lower than that in the conventional group, and the difference was statistically significant (P < 0.05). After intervention, the levels of serum albumin and prealbumin in the two groups were higher than those before intervention, the acute physiology and chronic health evaluation score (APACHE) was lower than that before intervention, and the levels of serum albumin and prealbumin in the fluid pressure measurement group were higher than those in the conventional group, and APACHE was lower than that in the conventional group, with statistical significance (P < 0.05). Conclusion The application of fluid manometry to monitor intestinal pressure in the early enteral nutrition treatment of patients with severe neurological conditions can improve the rate of enteral nutrition compliance and effectively reduce the enteral nutrition feeding intolerance of patients with severe neurological conditions.