〔Abstract〕 Objective To observe the clinical efficacy of Jinglian Siwu Ointment on the repair of acne indented scar wounds after fractional CO₂ laser treatment and its influence on epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). Methods A total of 80 patients with acne indented scars who were diagnosed and treated in from January 2022 to January 2023,admitted to Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into an observation group and a control group, with 40 cases in each group. Both groups of patients underwent fractional CO₂ laser treatment. The observation group applied Jinglian Siwu Ointment to the wounds, while the control group applied Moist Burn Ointment to the wounds, with a treatment course of 3 months. The duration of pain, complete wound healing time, visual analogue scales (VAS) score, skin barrier function-related indicators, quality of life score, and serum levels of EGF and bFGF were compared between the two groups after treatment. Results The VAS score of the observation group was lower than that of the control group, and the duration of pain and wound healing time were shorter than those of the control group, with statistically significant differences (P < 0.05). After treatment, the skin moisture content of the observation group was higher than that of the control group, while the transepidermal water loss and skin oil content were lower than those of the control group, with statistically significant differences (P < 0.05). After treatment, the self-perception, emotional function, and social function scores of the observation group were higher than those of the control group, with statistically significant differences (P < 0.05). After treatment, the serum levels of EGF and bFGF in the observation group were higher than those in the control group, with statistically significant differences (P < 0.05). Conclusion The external use of Jinglian Siwu Ointment can promote wound healing after laser surgery, which may be related to the up-regulation of the levels of growth factors such as serum EGF and bFGF.