〔Abstract〕 With the aggravation of social aging, the incidence rate of stroke remains high. In the clinical treatment of motor dysfunction (hemiplegia) caused by stroke, the rehabilitation of the ankle joint to a certain extent means the rehabilitation of the entire nervous system, and the rehabilitation of the ankle joint is the basis for gait training and a prerequisite for patients to walk on the ground. This study through an investigation into sample size calculation for clinical trials of intelligent ankle rehabilitation robots, aims to offer more robust data support for the precise selection development of future rehabilitation robotics, consequently enhancing the prospects of their implementation in clinical practice settings.