〔Abstract〕 The clinical data of 2 patients with hemophagocytic syndrome (HPS) caused by fungal infection who were hospitalized in the First Affiliated Hospital of Anhui University of Chinese Medicine from April 2022 to November 2022 were retrospectively analyzed from the aspects of clinical manifestations, laboratory tests, histocytology and diagnosis. The 2 cases diagnosed with HPS had persistent fever, accompanied by hemocytopenia, significant increase of ferritin and triglyceride. Fungi were found in bacteriology, histocytology revealed infiltration of hemophagocytic cells. Early identification of HPS by clinical features and timely detection of etiology are important for the prognosis of infection-induced HPS.