〔Abstract〕 Objective To investigate the application value of micro titanium plate internal fixation in the treatment of oral and maxillofacial fracture. Methods A total of 80 patients with oral and maxillofacial fracture who were admitted to the First Affiliated Hospital of Henan University of Science and Technology (Kaiyuan District) from April 2020 to July 2021 were selected and divided into micro titanium plate group and stainless steel plate group according to random group method, with 40 cases in each group. The micro titanium plate group was treated with the micro titanium plate internal fixation method, and the stainless steel plate group was treated with the stainless steel plate fixation method. Oral and facial muscle function, fracture healing and the incidence of complications were compared between the two groups. Results After operation, there was no significant difference in lip posture scores between the two groups (P > 0.05) . The other objects of appearance and posture scores and exercise scores in the micro titanium plate group were higher than those in the stainless steel plate group, and the differences were statistically significant (P < 0.05). The mouth opening of patients in the micro titanium plate group was higher than that in the stainless steel plate group, and the difference was statistically significant (P < 0.05). There was no significant difference in occlusal degree between the two groups (P > 0.05). The incidence of complications in the micro titanium plate group was lower than that in the stainless steel plate group, and the difference was statistically significant (P < 0.05). Conclusion Micro titanium plate internal fixation and stainless steel plate fixation both have good clinical effects on occlusal degree, but micro titanium plate internal fixation can more effectively promote the recovery of oral and facial muscle function, accelerate the healing speed of maxillofacial fracture, reduce the incidence of complications, and facilitate postoperative recovery of patients.