〔Abstract〕 Objective To evaluate the effect analysis of discontinuing intravenous analgesic pump at different time points after laparoscopic surgery in patients. Methods Sixty patients who underwent laparoscopic surgery at Dongyuan County People's Hospital from May to July 2022 were randomly divided into four groups: the non-use of analgesic pump group (Group A), the discontinuation of analgesic pump 24 hours after surgery group (Group B), the discontinuation of analgesic pump 48 hours after surgery group (Group C), and the discontinuation of analgesic pump 72 hours after surgery group (Group D). Visual analogue scales (VAS) scores, additional intravenous analgesic injections after surgery, hospital stay, cessation of oxygen therapy, bowel sounds and anal exhaust recovery time, and occurrence of adverse reactions were compared among the groups. Results The VAS scores of Group A were higher than the other three groups, while the VAS scores of Group C were lower than the other three groups, with statistical significance (P < 0.05). The hospital stay of Group A was longer than the other three groups, while the hospital stay of Group C was shorter than the other three groups, with statistical significance (P < 0.05). The proportion of patients requiring additional intravenous analgesic injections after surgery in Group A was higher than the other three groups, with statistical significance (P < 0.05), while there was no significant difference among Groups B, C, and D (P > 0.05). There was no significant difference in the occurrence of adverse reactions among the four groups (P > 0.05). Conclusion Discontinuing the intravenous analgesic pump 48 hours after surgery has a good effect on improving pain in patients, reducing hospital stay, while prolonging the use of the analgesic pump does not bring significant benefits.