〔Abstract〕 Objective To explore the differentiation and treatment laws of regulating neurotransmitters in insomnia patients using meridian theory and data mining methods. Methods After searching the literature on the treatment of insomnia patients based on the theory of meridians and collaterals in databases from China National Knowledge Infrastructure (CNKI)，Wanfang Data Knowledge Service Platform, VIP Database and other databases from January 2003 to May 2023, and aiming at improving the changes of neurotransmitters in insomnia patients, the point selection prescription of the included literature was extracted, the frequency analysis of high-frequency acupoints was carried out, and the channel normalization. correlation analysis and cluster analysis were carried out, and the network visualization analysis of the involved meridians was carried out. Results A total of 41 references were included in this study, including 41 acupoint prescriptions. There were 54 acupoints involved, among which 27 acupoints were used more than 3 times, involving a total of 12 meridians. The acupoint with the highest frequency of use was Baihui, and the meridian with the highest frequency of use after returning to the meridian was Du Meridian. The correlation analysis showed that the acupoints with high correlation degree during high-frequency use were Zhaohai, Baihui, Shenmen, and Sanyinjiao. The highest correlation degree among the meridians with high frequency was Foot Jueyin Liver Meridian → Foot Taiyang Bladder Meridian. The meridians with good correlation were Foot Jueyin Liver Meridian, Foot Taiyang Bladder Meridian, Du Meridian, Foot Shaoyang Gallbladder Meridian, and Hand Shaoyang Triple Burner Meridian. High frequency acupoint clustering can obtain 7 core acupoint selection combinations. Conclusion The core acupoint prescriptions for treating insomnia based on the theory of meridians are Baihui, Shenmen, and Sanyinjiao. The acupoints on the Du Meridian have the strongest correlation, and different combinations of acupoint prescriptions can improve the patient's neurotransmitters, thereby achieving the therapeutic effect of improving sleep.