〔Abstract〕 Objective To investigate the effect of Wenyang Tongmai decoction in the treatment of patients with chronic heart failure. Methods A total of 82 patients with chronic heart failure admitted to Pingdingshan Hospital of Traditional Chinese Medicine from August 2020 to December 2022 were selected and divided into a control group and an observation group according to simple random method, with 41 cases in each group.The control group was given conventional drug treatment, and the observation group was given Wenyang Tongmai decoction to assist conventional drug treatment. The clinical efficacy, cardiac function, oxidative stress response and serum indexes of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). After treatment, the left ventricular end systolic volume (LVESV), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) in the observation group were lower than those in the control group, and the left ventricular ejection fraction (LVEF) was higher than that in the control group, with statistical significances (P < 0.05). After treatment, the levels of malondialdehyde (MDA) and lipid peroxide (LPO) in the observation group were lower than those in the control group, while the levels of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in the observation group were higher than those in the control group, with statistical significance (P < 0.05). After treatment, the levels of cardiac troponin I (cTnI) and brain natriuretic peptide (BNP) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Wenyang Tongmai decoction can effectively improve clinical efficacy, improve cardiac function and relieve oxidative stress in patients with chronic heart failure.