〔Abstract〕 Objective To explore the effect of triple pre-rehabilitation nursing on the application and quality of life of patients with oral and maxillofacial malignant tumor flap transplantation. Methods One hundred and fifty patients of oral and maxillofacial malignant tumor flap transplantation who received treatment at Nanyang Stomatological Hospital from October 2019 and October 2022 were selected. They were divided into a control group and an observation group by drawing lots, with 75 cases in each group. The control group received conventional nursing care, and the observation group received triple pre-rehabilitation nursing care on the basis of the control group, and the indicators of nutritional status, complications, and quality of life of the two groups of patients were compared. Results Before intervention, there was no difference in the comparison of the four nutritional indexes (serum albumin, prealbumin, transferrin and hemoglobin) between the two groups of patients (P > 0.05). Compared with the control group, the observation group had high levels of all nutritional indexes in the 1d before surgery and the 7d after surgery. After the intervention, the quality of life scores of the observation group were higher than those of the control group (P < 0.05). Compared with the control group, patients in the observation group had low complications (P < 0.05). Conclusion Patients with oral and maxillofacial malignant tumor flap transplantation receive triple pre-rehabilitation nursing, and their nutritional status can be improved, complications can be effectively reduced, and the quality of life can be improved.