〔Abstract〕 Objective To explore the influence of compound radix arnebiae oil on erosive surface secondary infection of bullous dermatosis. Methods A total of 40 patients diagnosed with bullous dermatosis admitted to Dermatology Hospital of Jiangxi Province were enrolled between September 2021 and September 2022, and were classified into an observation group (20 cases) and a control group (20 cases) according to the random number table method. The patients in the control group were given symptomatic treatment and prednisone acetate tablet, while the patients in the observation group were treated with compound radix arnebiae oil on the basis of the control group. The therapeutic efficacy, onset time, skin damage regression time and hospital stay were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The visual analogue scales (VAS) score in the observation group after treatment was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). The skin exudation stop time, skin lesion regression time, and hospital stay in the observation group were significantly shorter compared with those in the control group, and the differences were statistically significant (P < 0.05). The secondary skin infection rate in the observation group was significantly lower at 5.00% (1/20) compared to the control group's rate of 30.00% (6/20), and the difference was statistically significant (P < 0.05). Conclusion The application of compound radix arnebiae oil is helpful to enhance the efficacy of erosive surface secondary infection of bullous dermatosis, relieve the pain of patients, shorten the exudation time, skin lesion regression time and hospital stay, and improve the secondary infection.