〔Abstract〕 Objective To observe the effects of Yishen Pinggan recipe on early renal damage caused by H-type hypertension， providing clinical basis for the prevention and treatment of H-type hypertension and its renal damage with Yishen Pinggan recipe. Methods A total of 67 patients with early renal damage caused by H-type hypertension admitted to the Department of Traditional Chinese Medicine, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 2014 to February 2015 were collected and divided into two groups by random number table method: 34 patients in the western medicine group and 33 patients in the Chinese-Western medicine group. The western medicine group was given losartan potassium + folic acid treatment, and the Chinese-Western medicine group was given Yishenpinggan Recipe + losartan potassium + folic acid treatment. After 3 months of intervention, the symptom changes of the two groups of patients were observed by the traditional Chinese Medicine(TCM) symptom scale, and the 24 h ambulatory blood pressure was measured by 24 h ambulatory blood pressure measurement. Serum homocysteine (Hcy), urinary microalbumin (mAlb) and urinary β2-microglobulin (β2-mg) were measured by enzyme-linked immunosorbent assay. Results After treatment, the total clinical effective rate in the ChineseWestern medicine group was 87.9 %, which was significantly higher than 76.5 % of the Western medicine group, and the difference was statistically significant (P < 0.05). After treatment, the 24 h mean systolic blood pressure, 24 h mean diastolic blood pressure, the levels of urinary mAlb, urinary β2-MG and serum Hcy were significantly decreased in two groups, and the differences were statistically significant (P < 0.01). Moreover, the improvement of symptoms was more obvious in the Chinese-Western medicine group, and the 24 h mean systolic blood pressure, 24 h mean diastolic blood pressure, the levels of serum Hcy, urinary mAlb and β2-MG were lower than those in the western medicine group, and the differences were statistically significant (P < 0.05). Conclusion Yishen Pinggan recipe combined with losartan potassium, folic acid can improve the symptoms, lower blood pressure,decrease the expression levels of serum Hcy and improve renal function of patients with renal damage caused by H-type hypertension.