〔Abstract〕 Objective To explore the clinical effect of calcium gluconate combined with oxytocin in the treatment of postpartum hemorrhage. Methods A retrospective selection was conducted on 120 postpartum hemorrhage postpartum women admitted to Fujian Maternal and Child Health Hospital from February 2020 to February 2023. According to different treatment methods, they were divided into a control group and an observation group, with 60 cases in each group. The control group was treated with oxytocin alone, while the observation group was treated with oxytocin combined with calcium gluconate. Compare the postpartum hemorrhage volume, clinical indicators, and clinical efficacy between the two groups of patients. Results At 1 hour, 2 hours, 4 hours, and 24 hours postpartum, the observation group had less hemorrhage volume than those in the control group, and the differences were statistically significant (P < 0.05). The observation group had shorter duration of hemostasis, placental delivery, hospitalization, and lochia compared to the control group, and longer duration of uterine contractions compared to the control group, with statistically significant differences (P < 0.05). The total offective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Compared with using oxytocin alone, the combination of oxytocin and calcium gluconate has a better clinical effect in the treatment of postpartum hemorrhage.