〔Abstract〕 Objective To observe the clinical effect of Jinzhen oral liquid combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia (MPP) (non-severe). Methods A total of 168 children diagnosed with MPP (non-severe) admitted to Yangjiang People's Hospital from January 2019 to January 2021 were randomly divided into an observation group and a control group according to the order of admission, 84 cases in each group.The observation group was treated with Jinzhen oral liquid combined with azithromycin, and the control group was treated with azithromycin. The clinical effects (the time of fever reduction and cough), serum inflammation indexes [Interleukin (IL) -2, IL-6 and hypersensitive C-reactive protein (HS-CRP)] before and after treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). After treatment, the serum levels of IL-2, IL-6 and hs-CRP in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Jinzhen oral liquid combined with azithromycin in the treatment of MPP children, can better relieve the symptoms of children, reduce inflammation.