〔Abstract〕 Objective To analyze the clinical effect of omeprazole enteric-coated capsule combined with Kangfuxin liquid in the treatment of patients with peptic ulcer. Methods A total of 84 patients with peptic ulcer admitted to Pingdingshan Maternal and Child Health Hospital from March 2020 to July 2022 were selected as the study objects and randomly divided into a control group and an observation group, with 42 cases in each group. The control group was treated with omeprazole enteric capsule alone, and the observation group was treated with omeprazole enteric-capsule combined with Kangfuxin solution. Clinical indicators, improvement time of clinical symptoms, clinical efficacy and occurrence of adverse reactions were compared between the two groups. Results After treatment, all clinical indexes in the two groups were lower than those before treatment, the clinical indexes in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). The improvement time of clinical symptoms in the observation group were shorter than those in the control group, and the differences were statistically significant (P < 0.05). The clinical efficacy rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The application of omeprazole enteric-coated capsule combined with Kangfuxin liquid in the treatment of patients with peptic ulcer can significantly improve various clinical indicators, shorten the time of symptom relief, and enhance clinical efficacy, and the combination of medication will not increase the occurrence of adverse reactions, and has safety.