〔Abstract〕 Objective To analyze the clinicopathological features and prognosis of 30 young patients with breast cancer. Methods Thirty young breast cancer patients (20 ~ 40 years old) admitted to the Second Affiliated Hospital of University of South China from January 2019 to May 2022 and 30 middle-aged and elderly patients with breast cancer (45 ~ 65 years old) admitted to the Second Hospital of the University of South China during the same period were selected as the study objects, and were set as an observation group and a control group, respectively, to compare the clinicopathological characteristics of the two groups of patients, and the clinical prognosis was analyzed. Results The percentages of invasive ductal carcinoma, tissue grade Ⅲ, lymph node metastasis and human epidermal growthfactor receptor-2 (Her-2) positive in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The percentages of invasive lobular carcinoma, tissue grade Ⅰ, estrogen receptor (ER) positive and progesterone receptor (PR) positive of the observation group was lower than those of the control group, the differences were statistically significant (P < 0.05). There was no significant difference in the molecular classification of breast cancer between the two groups (P > 0.05). After 12 months of follow-up, the mortality rate of the observation group was higher than that of the control group, and the survival rate was lower than that of the control group, with statistical significance (P < 0.05). Conclusion Young patients with breast cancer have clinicopathological features of lymph node metastasis, high HER-2 positive and high tissue grade, which are different from middle-aged and elderly patients with breast cancer, which may have a greater impact on the survival rate of patients and a poor prognosis.