〔Abstract〕 Objective To investigate the relationship between the change of liver stiffness measurement (LSM) and the reversal of liver fibrosis in chronic hepatitis B (CHB) patients after treatment. Methods A-total of 80 patients with CHB admitted to Chengwu Branch of the Second Hospital of Shandong University between April 2020 and August 2021 were selected as study subjects, all of whom had received antiviral treatment and were divided into two groups according to whether they had reversed liver fibrosis after treatment, namely the reversal group (38 patients) and the non-reversal group (42 patients). Baseline data [age, gender, history of alcohol consumption, smoking, body mass index (BMI)] and pretreatment laboratory biochemical indexes were collected, and ultrasound was performed to detect the LSM, to calculate the azotransferase to platelet count ratio (APRI), and the liver fibrosis index based on 4 factors (FIB-4). Multifactorial logistic regression was used to analyse the influencing factors of fibrosis reversal and to observe whether LSM had an effect on liver fibrosis reversal. Results The differences between the reversal group and the non-reversal group in terms of platelet count (PLT) > 300×10⁹ ·L^-1, hepatitis B virus deoxyribonucleic acid (HBV DNA) level, LSM grading, and ΔLSM were statistically significant (P < 0.05). The results of multifactorial logistic regression analysis showed that pretreatment PLT > 300×10⁹ ·L^-1 and pretreatment LSM 9.4 ~ 17.0 kPa, LSM > 17.0 kPa were the risk factors for hepatic fibrosis reversal (OR > 1, P ＜ 0.05), HBV DNA 4.0 ~ 7.0 lg IU·mL^-1 、HBV DNA > 7.0 lg IU·mL^-1 were not independent influencing factors for liver fibrosis reversal (P > 0.05). ΔLSM 5 ~ 10 kPa and ΔLSM > 10 kPa were protective factors for liver fiber reversal (OR < 1, P < 0.05). Conclusion Pre-treatment PLT > 300×10⁹ ·L^-1 and pre-treatment LSM 9.4 ~ 17.0 kPa and LSM > 17.0 kPa were risk factors for hepatic fibrosis reversal, and ΔLSM 5 ~ 10 kPa and ΔLSM > 10 kPa were protective factors for hepatic fiber reversal.