〔Abstract〕 T-cadherin, a unique member of the cadherin family, a negative regulator of axonal growth during neural differentiation, is also a hypermethylation-associated tumor suppressor molecule in many malignancies. An important role of T-cadherin is its ability to bind high molecular weight adiponectin in cardiovascular tissues, thereby mediating the cardioprotective effects of adiponectin, playing an important role in cardiovascular diseases. This paper reviews the biological role of T-cadherin in cardiovascular diseases.