〔Abstract〕 Objective To analyze the recurrence rate and risk factors of hysteroscopic endometrial polyp (EP) resection based on multivariate logistic regression model. Methods The clinical data of 110 EP patients hospitalized in Yongcoal Group General Hospital from June 2021 to June 2022 were retrospectively analyzed, and they were divided into a relapsed group (13 cases) and a non-recurrence group (97 cases) according to the prognosis 6 months after discharge (whether there was relapse or not), and compared the demographic and pathological data as well as the serological indexes of the two groups of patients, and analyzed the risk factors affecting the recurrence of EP after hysteroscopic EP resection. Results In this study, the recurrence rate after hysteroscopic EP resection was 11.82 % (13/110); the percentage of patients with combined polycystic ovary syndrome, no postoperative use of contraceptive pills, and the levels of serum interleukin (IL)-23, tumor necrosis factor (TNF)-α, luteinizing hormone (LH), and estradiol (E2) levels were statistically significant (P < 0.05) compared with the non-recurrence group. (E2) were statistically significant compared with the non-recurrence group (P < 0.05); multifactorial logistic regression analysis showed that the combination of polycystic ovary syndrome, the non-use of contraceptive pills postoperatively, and the high serum levels of IL-23, TNF-α, LH, and E2 were the risk factors for recurrence (OR > 1, P < 0.05). Conclusion Comorbid polycystic ovary syndrome, lack of postoperative contraceptive use, and high serum IL-23, TNF-α, LH, and E2 levels increase the risk of recurrence after hysteroscopic EP resection.