〔Abstract〕 Objective The correlation of serum neutrophils lymphocyte count ratio (NLR), growth differentiation factor-15 (GDF-15), transient receptor potential channel 1 (TRPC1) and cardiac function indexes in patients with heart failure (HF) was analyzed. Methods A total of 220 HF patients treated in Xinxiang First People's Hospital from June 2019 to December 2020 were selected as an observation group, and 220 healthy people who were examined in Xinxiang First People's Hospital during the same period were selected as a control group. Serum NLR, GDF-15 and TRPC1 levels of the two groups of subjects were detected. Echocardiography was used to detect the cardiac function of the two groups, and the inter-group comparison and correlation analysis of each index were performed. Results The ultrasonic left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) in the observation group were higher than those in the control group, and the left ventricular ejection fraction (LVEF) was lower than that in the control group, the differences were statistically significant (P < 0.05). The levels of serum NLR, GDF-15 and TRPC1 in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). In the observation group, Pearson correlation analysis showed that serum NLR, GDF-15 and TRPC1 were positively correlated with LAD and LVEDD (P < 0.05), and negatively correlated with LVEF (P < 0.05). Conclusion HF patients were often accompanied by elevated levels of serum NLR, GDF-15 and TRPC1, and the above indicators were correlated with the cardiac function indicators of patients.