〔Abstract〕 Objective To explore the effects of losartan combined with felodipine on renal function of patients with hypertension and chronic renal failure. Methods A retrospective analysis was performed on 104 patients with hypertension combined with chronic renal failure treated in the First Health Institute of Yunnan Provincial Government Offices Administration from March 2019 to January 2021, and they were divided into a control group and an observation group according to different treatment methods, with 52 cases in each group.The control group was treated with felodipine, and the observation group was treated with losartan on the basis of control group. Renal function index, blood pressure, blood potassium level, clinical efficacy and occurrence of adverse reactions were compared between the two groups. Results After treatment, the levels of diastolic blood pressure, systolic blood pressure, blood creatinine, urea nitrogen, 24 hours urinary protein and blood potassium in the two groups were lower than those before treatment, and the levels of the above indexes in the observation group was lower than those in the control group, the differences were statistically significant (P < 0.05). The clinical efficacy rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion The treatment of losartan combined with felodipine in patients with hypertension and chronic renal failure can effectively improve renal function, enhance clinical efficacy, and is safe and effective.