〔Abstract〕 Objective To compare clinical effect of two methods of endovascular radiofrequency ablation for the great saphenous varicose veins. Methods A total of 132 patients with the great saphenous varicose veins admitted to Nanyang Central Hospital from January 2019 to November 2020 were randomly divided into two groups, with 66 patients in each group. The main trunk of great saphenous vein was closed by Closefast and F-care intracavitary radiofrequency ablation, respectively. The surgical status, visual analogue scale (VAS) score, postoperative complication rate, saphenous vein closure rate, clinical venous severity score (VCSS) and chronic venous insufficiency questionnaire (CIVIQ) score of the two groups were compared. Results There was no significant difference in the diameter of the great saphenous vein, the length of venous ablation, the time to return to normal work after surgery, and the VAS score between the two groups (P > 0.05). The ablation time and total operation time of the F-care group were longer than those of the Closefast group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of postoperative complications between the two groups (P > 0.05). There was no significant difference in the closure rate of 1 month and 1 year after ultrasound examination between the two groups (P > 0.05). Compared with preoperative results, postoperative scores of VCSS and CIVIQ were significantly improved in both groups, with statistical significance (P < 0.05). There was no significant difference in scores of VCSS and CIVIQ between the two groups after surgery (P > 0.05). Conclusion F-care system is comparable to Closefast system in the closing of the great saphenous varicose vein, but the ablation time and total operation time of the F-care system are longer than that of the Closefast system.