〔Abstract〕 Objective To investigate the effect of Self-prepared Sanqi Shenqi decoction on clinical indexes of patients with stable angina pectoris (SAP). Methods A total of 94 SAP patients treated in The First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were selected and divided into a conventional group and a decoction group according to random number table method, with 47 cases in each group. The conventional group was treated with conventional western medicine, and the decoction group was treated with Self-prepared Sanqi Shenqi decoction on the basis of conventional treatment. The changes of clinical symptom index, blood lipid level, blood rheology index, blood flow velocity and serological related index were compared between the two groups after treatment. Results After treatment, the frequency of angina pectoris attack, duration of attack and dosage of nitroglycerin in the decoction group were lower than those in the conventional group, and the differences were statistically significant (P < 0.05). After treatment, the levels of triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the decoction group were lower than those in the conventional group, and the differences were statistically significant (P < 0.05). After treatment, whole blood high tangential viscosity (HBV), whole blood low tangential viscosity (LBV) and plasma viscosity (PV) in the decoction group were lower than those in the conventional group, while coronary blood flow velocity (CFV) was higher than that in the conventional group, with statistical significance (P < 0.05). After treatment, the serum levels of N-terminal B-type natriuretic peptide (NT-probNP), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in the decoction group were lower than those in the conventional group, and the level of nitric oxide (NO) was higher than that in the conventional group, the differences were statistically significant (P < 0.05). Conclusion Self-prepared Sanqi Shenqi decoction can further relieve the clinical symptoms of patients with SAP.