〔Abstract〕 Objective To study the influential factors of urinary sepsis after ureteral flexible lithotripsy. Methods 120 patients undergoing lithotripsis admitted to Shangrao People's Hospital from June 2019 to June 2022 were selected as the study objects. 60 patients with urinary sepsis were selected as the occurrence group, and 60 patients without urinary sepsis were selected as the nonoccurrence group. The influencing factors of patients with concurrent urinary sepsis were analyzed. Results There were significant differences in gender, stone size, operation time, diabetes mellitus and urine culture between the two groups (P < 0.05). Multivariate logistic regression analysis showed that female, stone size, operation time, diabetes mellitus and positive urine culture were independent risk factors for urinary sepsis after ureteral flexible lithotripsy (P < 0.05). Conclusion Urogenic sepsis after ureteral flexible lithotripsy is related to the gender of the patient, stone size, operation time, diabetes mellitus and urine culture factors. Therefore, before surgical treatment, it is necessary to evaluate and manage the relevant factors of patients. For women, patients with larger stones, long operation time, diabetes mellitus, and positive urine culture, it is necessary to strengthen postoperative observation and care, and timely detection and treatment of complications.