〔Abstract〕 Objective To analyze the therapeutic effect of bronchoalveolar lavage with fiberoptic bronchoscopy on patients with refractory mycoplasma pneumonia. Methods Ninety-five patients with refractory mycoplasma pneumonia who were treated in Zhengzhou People's Hospital from May 2022 to January 2023 were selected and divided into a control group and an observation group according to different treatment methods. Forty-five patients in the control group were treated with conventional symptomatic treatment, and 50 patients in the observation group were treated with bronchoalveolar lavage under fiberoptic bronchoscope on the basis of the control group. The clinical treatment efficiency was compared between the two groups of patients, and the serum inflammatory factors, symptom scores, pulmonary ventilation function, arterial blood gas, chest lung compliance and quality of life scores were compared between the two groups before and after 7 days of treatment. Results The clinical total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of serum inflammatory factor, symptom scores, pulmonary ventilation function and arterial blood gas indicators, chest lung compliance, and quality of life scores of the two groups of patients were better than those before treatment, and the above indicators in the observation group were better than those in the control group, with statistically significant differences (P < 0.05). Conclusion After the onset of refractory mycoplasma pneumonia in patients, bronchoalveolar lavage with fiberoptic bronchoscopy can enhance the patient's disease control effect, more effectively reduce symptoms and inflammatory reactions, and have a good improvement effect on lung function, arterial blood gas status, chest lung compliance, and quality of life.