〔Abstract〕 Corona virus disease 2019 (COVID-19) belongs to the category of “pestilence” of traditional Chinese medicine (TCM). The TCM name of this disease is determined as “COVID-19 pestilence” in this paper, through data mining of TCM diagnosis and treatment guideline of COVID-19 in various regions. TCM has a long history and rich experience in the prevention and treatment of epidemic diseases and formed a unique system of treatment with differential diagnosis. This system focuses on the combination of syndrome differentiation and disease differentiation. For syndrome differentiation analysis of COVID-19 pestilence, apply syndrome differentiation of eight principles, six meridians, Wei Qi Ying Xue and triple energizer. Disease differentiation analysis is based on etiology, character, location of and other aspects of COVID-19 pestilence. The aim is to clarify the pathogenesis and etiology of COVID-19 pestilence, and provide references and ideas for the prevention and treatment of COVID-19 pestilence.