〔Abstract〕 Objective To explore the clinical effect of Huayu Xiaozheng Prescription on patients with ectopic pregnancy. Methods A total of 89 patients with ectopic pregnancy admitted to Hunan Maternal and Child Health Hospital from March 2020 to May 2022 were selected and divided into an observation group (45 cases) and a control group (44 cases) according to random number table method. The control group was treated mainly with western medicine, and the observation group was treated with Huayu Xiaozheng prescription on the basis of the control group. After the treatment, the serum inflammatory factors and sex hormones levels of the two groups were compared, and the clinical efficacy of the two groups was compared during the follow-up period of 3 months. Results After treatment, the levels of serum interleukin (IL) -33 and soluble suppression of tumorigenicity-2 (sST2) in the observation group were lower than those in the control group, with statistical significance (P < 0.05). After treatment, the level of serum progesterone (P) in the observation group was higher than that in the control group, and the level of serum human chorionic gonadotropin β (β-hCG) was lower than that in the control group, the differences were statistically significant (P < 0.05). The time for β-HCG to return to normal, the time for abdominal pain to disappear, the time for abnormal vaginal bleeding and the time for mass to disappear in the observation group were shorter than those in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of the observation group was 93.33%, which was higher than that of the control group (77.27%), and the difference was statistically significant (P < 0.05). Conclusion Huayu Xiaozheng prescription for ectopic pregnancy can effectively reduce the level of inflammatory factors, improve the level of sex hormones, and promote the recovery of the disease.