〔Abstract〕 Objective To investigate the effects of transabdominal preperitoneal (TAPP) on postoperative pain and quality of life in patients with inguinal hernia. Methods 90 patients with inguinal hernia admitted to Pingdingshan First People's Hospital from March 2018 to March 2020 were selected and randomly divided into an observation group and a control group, with 45 cases in each group. The control group was treated with traditional tension-free hernia repair, while the observation group was treated with TAPP. Postoperative indexes, pain, complications, recurrence and quality of life were compared between the two groups. Results The intraoperative blood loss, operation time, hospital stay and return to work time in the observation group were significantly less than those of the control group, the differences were statistically significant (P < 0.05). At 1 day, 3 days and 1 week after surgery, visual analogue scales (VAS) score of the observation group was lower than that of the control group, the differences were statistically significant (P < 0.05). The incidence of postoperative complications in the observation group was significantly lower than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, scores of quality of life in the two groups were increased, and scores of quality of life in the observation group were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion The application of TAPP in patients with inguinal hernia can reduce the damage to patients, reduce the postoperative pain and complication rate, and improve the quality of life of patients.