〔Abstract〕 Objective To study the effect of albumin injection combined with Yinzhihuang granules on neonatal jaundice treatment. Methods 60 cases of neonatal jaundice children admitted to Ji 'an Maternal and Child Health Hospital from July 2019 to June 2022 were divided into two groups according to different treatment plans. 30 cases in the control group were given albumin intravenous injection treatment, and 30 cases in the observation group were given albumin intravenous injection and Yinzhihuang granules treatment. The basic clinical indexes, bilirubin levels, serological indexes, immune function indexes, clinical efficacy and the occurrence of adverse drug reactions were compared between the two groups. Results The duration of jaundice resolution and hospitalization in the observation group were shorter than those in the control group, and the number of stool per day was more than that in the control group, the difference was statistically significant (P < 0.05). After treatment, the levels of bilirubin, serological indexes and CD8⁺ in the observation group were lower than those in the control group, while the levels of CD4⁺ and CD4⁺ /CD8⁺ were higher than those in the control group, with statistical significance (P < 0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The combination of albumin injection and Yinzhihuang granules in the treatment of neonatal jaundice can effectively reduce the level of bilirubin, improve the serological index and immune function of children with high safety.