〔Abstract〕 Objective To investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) on biochemical indicators of liver function and hepatocyte morphology during hepatic ischemia/reperfusion (I/R). Methods Twelve male SD rats were randomly divided into control group, model group, model + false TEAS group, and model + TEAS group with 3 rats in each group. The control group received laparotomy without vascular clipping, the model group was established as a nonfatal hepatic segment (70 %) I/R model, the model + false TEAS group took comfort patch and opened it for 5 mm without any electrical stimulation, and the model + TEAS group received TEAS intervention, which was performed for 3 times during the experiment. The changes of liver function indexes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum, acetyltransferase (CAT), glutathione (GSH) in liver tissues of rats in each group were determined by automatic biochemical analyzer and immunohistochemical techniques. Hematoxylin-eosin (HE) staining were performed on liver tissues. Inflammatory cell infiltration were observed in each section. Results ALT and AST contents in the model group, model + false TEAS group and model + TEAS group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Compared with the model group, ALT and AST contents in the model + TEAS group were significantly decreased, and the differences were statistically significant (P < 0.05). The contents of GSH and CAT in the model group, model + false TEAS group and model + TEAS group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Compared with the model group, the contents of GSH and CAT in the model + TEAS group increased to varying degrees, but there was no significant difference among all groups (P ＞ 0.05). HE staining showed that the inflammatory cell infiltration in the Tetras + model group was obviously better than that in the model group. Conclusion TEAS can effectively ameliorate liver function injury during liver I/R and improve morphological changes of liver cells after liver I/R, thus playing a protective role in liver.