〔Abstract〕 Objective To explore the effects of mindfulness-based stress reduction therapy (MBSR) combined with music intervention on mental state and pain degree of patients undergoing dental implant surgery. Methods A total of 110 patients receiving dental implant surgery from the First People's Hospital of Shangqiu from May 2017 to May 2019 were selected as the study objects. All patients were divided into a control group and an observation group by random number table method, with 55 cases in each group. The control group received routine nursing intervention, and the observation group received MBSR combined with music intervention on the basis of the control group. The psychological state and pain degree of the two groups were compared after intervention. Results After intervention, patients in the observation group were evaluated on self-rating anxiety scale (SAS) and Stouthard's dental anxiety inventory (DAI), and the scores were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). The scores of visual analog scale (VAS) of the observation group at 6 h, 24 h and 48 h after surgery were significantly lower than those of the control group, the differences were statistically significant (P < 0.05). Conclusion MBSR combined with music intervention can significantly reduce anxiety and depression symptoms, reduce pain, and improve prognosis and quality of life in patients with dental implant surgery.