〔Abstract〕 Objective To explore the therapeutic effect of Shenling Baizhu Granules combined with Tongxie Yaofang on diarrhea type irritable bowel syndrome of liver depression and spleen deficiency syndrome. Methods A retrospective analysis was conducted on the clinical data of 105 children with diarrhea type irritable bowel syndrome of liver stagnation and spleen deficiency syndrome admitted to Jun'an Hospital of Shunde District, Foshan City, from January 2018 to January 2020. They were divided into group A (52 cases) and group B (53 cases) based on the medication method. Patients in group A were treated with trimebutine maleate tablets, and patients in group B were treated with Shenling Baizhu Granules combined with Tongxie Yaofang. The clinical treatment effectiveness, traditional Chinese medicine syndrome scores, and recurrence rate between the two groups were compared. Results The total effective rate of group B patients was 96.23 %, which was higher than 82.69 % group A, and the difference was statistically significant (P < 0.05). After treatment, the scores of diarrhea, abdominal distension, abdominal pain, and chest and hypochondriac fullness in both groups of patients decreased to varying degrees, and the scores of diarrhea, abdominal distension, abdominal pain, and chest and hypochondriac fullness in group B were lower than those in group A, with statistical significance (P < 0.05). After one month of follow-up, the recurrence rate of group B patients was 1.89 %, lower than 15.38 % of group A, and the difference was statistically significant (P < 0.05). Conclusion The combination of Shenling Baizhu Granules and Tongxie Yaofang has a good therapeutic effect and a low recurrence rate in the treatment of diarrhea type irritable bowel syndrome with liver depression and spleen deficiency syndrome.