〔Abstract〕 Objective To investigate the clinical effect of Yixin Huoxue Jiangya decoction on hypertension with Qi deficiency and blood stasis syndrome. Methods A total of 88 patients with hypertension admitted to Yellow River Central Hospital from October 2019 to October 2021 were selected and divided into a control group and an observation group according to random number table method, with 44 patients in each group. The control group was treated with conventional western medicine, and the observation group was treated with Yixin Huoxue Jiangya decoction on the basis of the control group for 2 months. The clinical efficacy, blood pressure level, hemorheology indexes and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 95.45 %, which was higher than 79.55 % of the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of the systolic blood pressure and diastolic blood pressure of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of whole blood high tangential viscosity (HBV), plasma viscosity (PV), whole blood low tangential viscosity (LBV) and hematocyte (HCT) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Yixin Huoxue Jiangya decoction can enhance the curative effect of hypertension, reduce the blood pressure level of patients, and correct the abnormal blood rheology.