〔Abstract〕 Objective To investigate the efficacy and safety of self-designed Yangqi Jianfei decoction combined with Tiotropium bromide in the treatment of stable chronic obstructive pulmonary diseases (COPD) with lung qi deficiency. Methods 64 patients with stable COPD treated in the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to January 2022 were divided into a control group (tiotropium bromide treatment) and an observation group (self-designed Yangqi Jianfei decoction combined with tiotropium bromide treatment). The differences of lung function, traditional Chinese medical syndrome score, 6 minutes walk test (6MWT) and COPD assessment test (CAT) were compared between the two groups before and after treatment. Results Forced expiratory volume in first second (FEV1), FEV1% and FEV1/ forced vital capacity (FVC) after treatment in the two groups were improved in different degrees compared with before treatment, and FEV1, FEV1% and FEV1/FVC in the observation group were higher than those in the control group after treatment, the differences were statistically significant (P < 0.05). The TCM syndrome scores of the two groups were decreased to different degrees after treatment, and the TCM syndrome score of the observation group was lower than that of the control group after treatment, the differences were statistically significant (P < 0.05). Compared with before treatment, 6MWT in the two groups was improved to different degrees, and CAT score decreased to different degrees. Moreover, 6MWT in the observation group was further than that in the control group after treatment, and CAT score was lower than that in the control group, with statistical significance (P < 0.05). No obvious adverse reaction was observed in the two groups. Conclusion Self-designed Yangqi Jianfei decoction combined with Tiotropium bromide can significantly improve the cardiopulmonary function, reduce clinical symptoms, improve quality of life in stable COPD with lung qi deficiency patients, and has the advantages of high efficiency and safety.