〔Abstract〕 Objective To investigate the effect of Jianggu yishen decoction on the recovery after minimally invasive crenel lateral lumbar interbody fusion (CLIF) of personalized 3D printed spine. Methods Fifty patients with lumbar degenerative scoliosis who received CLIF treatment in Henan Luoyang Orthopedic Hospital from January 2019 to January 2020 were selected. among them, 24 patients treated with surgery alone were included in the control group, and 26 patients treated with Jiangu Yishen decoction after CLIF were included in the observation group. The clinical indicators, clinical symptom scores, the changes of oswestry disability index (ODI) scores before surgery, 2 weeks after surgery, 1 month after surgery and prognosis (1 year after surgery) were compared between the two groups. The correction effect was observed 1 year after surgery. Results The postoperative drainage volume of the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). The scores of lower limb numbness, lumbar pain, walking impairment and sensory impairment in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). At 2 weeks and 1 month after surgery, ODI scores in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). The cobb angle, pelvic tilt angle, lumbar lordosis angle, sagittal plane axial distance and coronal plane balance were all lower in the two groups than before surgery, with statistical significance (P < 0.05). There was no significant difference in preoperative and prognostic indexes between the two groups (P > 0.05). Conclusion Jianggu yishen decoction can promote postoperative recovery of patients with lumbar degenerative scoliosis treated with personalized 3D printing spinal CLIF surgery, further alleviate clinical symptoms, and assist in improving postoperative lumbar function.