〔Abstract〕 Objective To study the clinical efficacy of ergotrine maleate combined with carprost amine triol injection in the treatment of postpartum hemorrhage and its influence on coagulation function. Methods A total of 132 patients with postpartum hemorrhage admitted to the 73rd Group Military Hospital of the People's Liberation Army of China from June 2021 to February 2022 were selected as the research objects and divided into observation group and control group according to random number table method, with 66 cases in each group. The control group was treated with ergotrine maleate, the observation group was treated with ergotrine maleate combined with carprost amine triol injection. The clinical effects of the two groups were compared after treatment. The changes of coagulation function indexes [serum fibrinogen (FIB), thrombin time (TT), activated partial thrombin time (APTT), prothrombin time (PT)] before and after treatment were compared between the two groups. Blood loss at 2 hours and 24 hours after medication was compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group after treatment, and the difference was statistically significant (P < 0.05). After treatment, the levels of FIB, TT, APTT and PT in the observation group were significantly lower than those of the control group, and the blood loss at 2 h and 24 h after medication was significantly lower than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Patients with postpartum hemorrhage treated with ergotrine maleate combined with carprost amine triol injection have significant effects, which can effectively improve their coagulation indexes and reduce postpartum bleeding volume.