〔Abstract〕 Objective To observe the correlation between the serum levels of soluble suppression of tumorigenicity-2 (sST2), rheumatoid factor (RF), anti cyclic citrullinated peptide (CCP) antibodies and the therapeutic indexes of rheumatoid arthritis (RA). Methods 72 RA patients admitted to Zhengzhou People's Hospital from January 2020 to January 2022 were selected for standardized treatment for 6 courses. The clinical efficacy of the patients was observed, and the serum levels of sST2, RF, CCP antibodies and conventional efficacy indicators [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Chinese full name (DAS28)] were compared before and after treatment. The correlation between serum sST2, RF, CCP antibodies and clinical efficacy, as well as various conventional efficacy indicators was analyzed. Results The total effective rate of 72 patients after treatment was 91.67%; After treatment, the serum levels of sST2, RF, CCP antibody, DAS28 score, ESR, CRP in patients were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05); The correlation analysis results showed that the serum levels of sST2, RF, CCP antibodies in patients were positively correlated with clinical efficacy, as well as with conventional efficacy indicators DAS28, ESR, and CRP. Conclusion There is a clear correlation between serum sST2, RF, CCP antibodies and RA efficacy, which can provide reference for the evaluation of RA efficacy.