〔Abstract〕 Objective To investigate the characteristics of blood pressure variability in patients with chronic heart failure (CHF) and hyperuricemia (HUA) , and to analyze the correlation between uric acid and blood pressure variability. Methods A total of 100 patients with CHF admitted to Xingtan Hospital, Shunde Hospital of Southern Medical University from February 2022 to October 2022 were selected as research objects, and divided into CHF group (without HUA) and CHF+HUA group according to whether the patients had HUA. Uric acid, N-terminal B-type natriuretic peptide (NT-proBNP) , blood pressure variability index [ (24 hours systolic blood pressure (SBP), 24 hours diastolic blood pressure (DBP) , daytime (d) SBP, dDBP, night (n) SBP, nDBP, 24h SBP standard deviation (sd) , 24h DBP-sd, dDBP-sd, dDBP-sd, nSBP-sd, nDBP-sd) ]. Spearman correlation was used to analyze uric acid and NT-proBNP, 24h SBP, 24h DBP, dSBP, dDBP, nSBP, nDBP, 24h SBP-sd, 24h DBP-sd, dSBP-sd, dDBP-sd, nSBP-sd, nDBP-sd. Results The uric acid, NT-proBNP and all blood pressure variability indexes in CHF+HUA group were significantly higher than those in CHF group, with statistical significance (P < 0.05) . Spearman correlation analysis showed that uric acid was positively correlated with NT-proBNP and all indexes of blood pressure variability in CHF+HUA group (r > 0, P < 0.05) . Conclusion The blood pressure variability indexes in CHF patients with HUA were significantly higher than those in CHF patients without HUA. Elevated uric acid can lead to abnormal blood pressure in CHF patients. In clinical practice, uric acid should be closely detected and actively treated to improve the prognosis of CHF patients.