〔Abstract〕 Objective To explore the effect of "Internet + " mode teaching in nursing teaching of hepatobiliary and pancreatic surgery. Methods 200 nursing students from Henan Provincial People's Hospital from January 2022 to October 2022 were selected as research objects, and divided into control group and observation group according to random number table grouping method, with 50 cases in each group. The control group adopted the conventional nursing teaching mode, while the observation group adopted the "Internet + " teaching mode to compare the assessment results of the practice nursing students in the two groups. Results The assessment results of the practice nursing students in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion The use of "Internet + " teaching mode in the nursing teaching of hepatobiliary and pancreatic surgery can improve the learning ability of test scores and critical thinking ability of nursing students, and make them obtain higher teaching satisfaction.