〔Abstract〕 Objective To explore the clinical effect of eucalyptus pine-enteric soft capsules combined with inhaled acetyl cysteamine solution in the treatment of chronic obstructive pulmonary disease (COPD). Methods A total of 60 COPD patients admitted to Xiamen Tong 'an District Hospital of Traditional Chinese Medicine from June 2020 to February 2022 were divided into two groups with 30 patients in each group. The control group was treated with acetyl cysteamine solution for inhalation, while the observation group was treated with eucalyptus and lime pine-enteric soft capsules combined with acetyl cysteamine solution for inhalation.The therapeutic effect of the two groups was compared. Results Compared with the control group, the total effective rate in the observation group was higher, the forced expiratory volume in the first second (FEV1), the ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) after treatment were higher than those in the control group, the time of symptom disappearance was shorter than that in the control group, and the score of chronic obstructive pulmonary Disease Evaluation Test Scale (CAT) was lower than the control group.The difference was statistically significant (P < 0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05). Conclusion In the treatment of COPD patients with eucalyptus lime pine-enteric soft capsules combined with inhaled acetyl cysteamine solution, good clinical effects were achieved without increasing adverse reactions, with high safety, and effective improvement of lung function and respiratory conditions.