〔Abstract〕 Objective To explore the effects of different antacids combined with octreotide on gastrointestinal bleeding in patients with liver cirrhosis. Methods A total of 80 patients with liver cirrhosis complicated with gastrointestinal bleeding treated in Xinxiang Central Hospital from May 2020 to May 2022 were randomly divided into an observation group and a control group. 40 cases in the control group were treated with omeprazole, and 40 cases in the observation group were treated with omeprazole plus ilaprazole. The clinical efficacy, treatment and adverse reactions of the two groups were evaluated. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). The rebleeding rate of the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). The hospitalization time and hemostasis time of the observation group were shorter than those of the control group, and the differences were statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Omeprazole + Eprrazole combined with octreotide has good efficacy in the treatment of patients with cirrhosis complicated with digestive tract bleeding, which can shorten the duration of hospitalization, reduce the amount of blood loss and rebleeding rate of patients, and reduce the secretion of gastric acid, with relatively high safety and not easy to cause adverse reactions.